N-of-1 Trial of a Statin, Placebo, or No Treatment to Assess Side Effects
The first report of the SAMSON trial at Imperial College London, published as correspondence. People who had stopped statins because of side effects rotated through periods taking a statin, an identical placebo and no tablet, in random order, scoring their symptoms daily. Most of the symptom burden experienced on the statin was also present on placebo. The full report followed in 2021. This is general information, not medical advice.
The first report of the SAMSON trial at Imperial College London, published as correspondence. People who had stopped statins because of side effects rotated through periods taking a statin, an identical placebo and no tablet, in random order, scoring their symptoms daily. Most of the symptom burden experienced on the statin was also present on placebo. The full report followed in 2021. This is general information, not medical advice.
Written from the crossref record read on 8 October 2026, with the full trial report.
What our sources record
Reproduced as it was written when this source was checked, figures and all.
Wood, F. A., Howard, J. P., Finegold, J. A., Nowbar, A. N., and colleagues, with Francis, D. P. (2020). 'N-of-1 trial of a statin, placebo, or no treatment to assess side effects.' New England Journal of Medicine, 383(22), 2182-2184. doi:10.1056/NEJMc2031173. Correspondence, first report of SAMSON.