Susumu Tonegawa

Susumu Tonegawa

Susumu Tonegawa is a neuroscientist and senior author of the 2012 and 2013 engram studies and co-author of the 2020 review.

Who they are

Susumu Tonegawa is a neuroscientist and senior author of the 2012 and 2013 engram studies and co-author of the 2020 review. On this site the name is tied to Engram, Optogenetics.

Key papers

Josselyn, S. A., & Tonegawa, S. (2020). Memory engrams: Recalling the past and imagining the future. Science, 367(6473), eaaw4325.

Liu, X., Ramirez, S., Pang, P. T., Puryear, C. B., Govindarajan, A., Deisseroth, K., & Tonegawa, S. (2012). Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature, 484(7394), 381-385.

Ramirez, S., Liu, X., Lin, P.-A., Suh, J., Pignatelli, M., Redondo, R. L., Ryan, T. J., & Tonegawa, S. (2013). Creating a false memory in the hippocampus. Science, 341(6144), 387-391.

Key ideas

Engram: The lasting physical change an experience leaves in a specific group of brain cells, whose reactivation brings the memory back.

Optogenetics: A method that makes chosen cells respond to light, used to switch tagged memory cells on in mice.

Sources

  1. Josselyn, S. A., & Tonegawa, S. (2020). Memory engrams: Recalling the past and imagining the future. Science, 367(6473), eaaw4325.
  2. Liu, X., Ramirez, S., Pang, P. T., Puryear, C. B., Govindarajan, A., Deisseroth, K., & Tonegawa, S. (2012). Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature, 484(7394), 381-385.
  3. Ramirez, S., Liu, X., Lin, P.-A., Suh, J., Pignatelli, M., Redondo, R. L., Ryan, T. J., & Tonegawa, S. (2013). Creating a false memory in the hippocampus. Science, 341(6144), 387-391.