Functional connectivity in the resting brain: a network analysis of the default mode hypothesis
Michael Greicius and three colleagues test the default mode hypothesis with a network analysis. They define the posterior cingulate cortex and the ventral anterior cingulate cortex as regions whose activity fell during a working-memory task, then examine how those regions are coupled at rest. The posterior cingulate is strongly coupled with the ventral anterior cingulate and several other regions implicated in the default mode network. During a visual processing task the connectivity maps are virtually identical to those at rest. Three lateral prefrontal regions that were more active during the cognitive task show inverse correlations with the posterior cingulate at rest, which the authors suggest is a mechanism for attenuating default mode activity during cognitive processing. They describe it as the first resting-state connectivity analysis of the default mode and the most compelling evidence to date for a cohesive default mode network. This page cites the paper for the move from a map of decreases to a connected network.
Michael Greicius and three colleagues test the default mode hypothesis with a network analysis. They define the posterior cingulate cortex and the ventral anterior cingulate cortex as regions whose activity fell during a working-memory task, then examine how those regions are coupled at rest. The posterior cingulate is strongly coupled with the ventral anterior cingulate and several other regions implicated in the default mode network. During a visual processing task the connectivity maps are virtually identical to those at rest. Three lateral prefrontal regions that were more active during the cognitive task show inverse correlations with the posterior cingulate at rest, which the authors suggest is a mechanism for attenuating default mode activity during cognitive processing. They describe it as the first resting-state connectivity analysis of the default mode and the most compelling evidence to date for a cohesive default mode network. This page cites the paper for the move from a map of decreases to a connected network.
Written from the abstract on Crossref, read 2026-10-23.
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Greicius, M. D., Krasnow, B., Reiss, A. L., & Menon, V. (2003). Functional connectivity in the resting brain: a network analysis of the default mode hypothesis. Proceedings of the National Academy of Sciences, 100(1), 253-258. doi:10.1073/pnas.0135058100