Memory engrams: Recalling the past and imagining the future
Josselyn and Tonegawa, Science 367(6473), 2020, eaaw4325. Review tracing the engram concept to Semon's 1904 proposal that experience activates cells that undergo lasting change and whose reactivation drives recall; covers new technologies to image and manipulate engram cells and evidence that engrams depend on neuronal excitability and synaptic plasticity.
Josselyn and Tonegawa, Science 367(6473), 2020, eaaw4325. Review tracing the engram concept to Semon's 1904 proposal that experience activates cells that undergo lasting change and whose reactivation drives recall; covers new technologies to image and manipulate engram cells and evidence that engrams depend on neuronal excitability and synaptic plasticity.
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Josselyn, S. A., & Tonegawa, S. (2020). Memory engrams: Recalling the past and imagining the future. Science, 367(6473), eaaw4325. doi:10.1126/science.aaw4325 https://doi.org/10.1126/science.aaw4325