Hyperdopaminergic Mutant Mice Have Higher “Wanting” But Not “Liking” for Sweet Rewards
Pecina, Cagniard, Berridge, Aldridge and Zhuang used a genetic mutant approach to ask what dopamine does in natural reward. A dopamine transporter knockdown mutation preserving only a tenth of normal transporter, and therefore leaving mutant mice with roughly seventy per cent elevated synaptic dopamine, was used to separate incentive motivation from hedonic impact. The hyperdopaminergic mice ate and drank more, learned a runway task for a sweet reward faster, left the start box more quickly, paused less, resisted distraction better and proceeded more directly to the goal, all of which indicates greater incentive salience attributed to the reward. In an affective taste reactivity test, the taste of sucrose did not elicit higher orofacial liking reactions from the same animals. The authors conclude that chronically elevated extracellular dopamine facilitates wanting and incentive learning without increasing liking for the hedonic impact of sweet tastes. This is the demonstration behind the distinction.
Pecina, Cagniard, Berridge, Aldridge and Zhuang used a genetic mutant approach to ask what dopamine does in natural reward. A dopamine transporter knockdown mutation preserving only a tenth of normal transporter, and therefore leaving mutant mice with roughly seventy per cent elevated synaptic dopamine, was used to separate incentive motivation from hedonic impact. The hyperdopaminergic mice ate and drank more, learned a runway task for a sweet reward faster, left the start box more quickly, paused less, resisted distraction better and proceeded more directly to the goal, all of which indicates greater incentive salience attributed to the reward. In an affective taste reactivity test, the taste of sucrose did not elicit higher orofacial liking reactions from the same animals. The authors conclude that chronically elevated extracellular dopamine facilitates wanting and incentive learning without increasing liking for the hedonic impact of sweet tastes. This is the demonstration behind the distinction.
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Peciña, S., Cagniard, B., Berridge, K. C., Aldridge, J. W., & Zhuang, X. (2003). 'Hyperdopaminergic mutant mice have higher wanting but not liking for sweet rewards.' Journal of Neuroscience, 23(28), 9395-9402. Dopamine transporter knockdown mice with roughly seventy per cent elevated synaptic dopamine showed raised incentive motivation for a sweet reward without raised affective liking reactions to its taste. doi:10.1523/jneurosci.23-28-09395.2003
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https://doi.org/10.1523/jneurosci.23-28-09395.2003
DOI: 10.1523/jneurosci.23-28-09395.2003