Creating a false memory in the hippocampus
Ramirez, Liu, Lin, Suh, Pignatelli, Redondo, Ryan and Tonegawa, Science 341(6144), 2013, 387-391. Dentate gyrus or CA1 neurons active in one context were labelled with channelrhodopsin-2 and reactivated by light during fear conditioning in a different context; the dentate gyrus group froze more in the original context where no shock was given; the false memory engaged downstream regions like natural fear recall; authors concluded a fear memory can be generated artificially.
Ramirez, Liu, Lin, Suh, Pignatelli, Redondo, Ryan and Tonegawa, Science 341(6144), 2013, 387-391. Dentate gyrus or CA1 neurons active in one context were labelled with channelrhodopsin-2 and reactivated by light during fear conditioning in a different context; the dentate gyrus group froze more in the original context where no shock was given; the false memory engaged downstream regions like natural fear recall; authors concluded a fear memory can be generated artificially.
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Ramirez, S., Liu, X., Lin, P.-A., Suh, J., Pignatelli, M., Redondo, R. L., Ryan, T. J., & Tonegawa, S. (2013). Creating a false memory in the hippocampus. Science, 341(6144), 387-391. doi:10.1126/science.1239073 https://doi.org/10.1126/science.1239073