Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study
[STRUCTURED ABSTRACT AND RESULTS PARAGRAPH READ IN FULL AT SOURCE, the BMJ article page; THE FULL BODY WAS NOT READ] Wootton, R. E., Lawn, R. B., Millard, L. A. C., Davies, N. M., Taylor, A. E., Munafo, M. R., Timpson, N. J., Davis, O. S. P., Davey Smith, G., & Haworth, C. M. A. (2018). 'Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study.' BMJ 362, k3788. doi:10.1136/bmj.k3788. THE SINGLE MOST IMPORTANT NEGATIVE RESULT IN THE FILE. Two-sample bidirectional Mendelian randomisation on genome-wide association summary data with participant numbers from 83,198 to 339,224, plus a follow-up in 337,112 UK Biobank participants, across eleven cardiometabolic outcomes including coronary artery disease and myocardial infarction. Result, verbatim: 'Evidence of a causal effect of body mass index on subjective wellbeing was seen; each 1 kg/m2 increase in body mass index caused a -0.045 (95% confidence interval -0.084 to -0.006, P=0.02) standard deviation reduction in subjective wellbeing ... No clear evidence of a causal effect was seen between subjective wellbeing and the other cardiometabolic health measures, in either direction.' The only causal arrow found ran from body mass index to lower wellbeing; the arrow from wellbeing to heart disease was absent in both directions. CONSTRUCT CAVEAT, WHICH MUST PRECEDE ANY USE: the exposure is subjective wellbeing and NOT dispositional optimism, and searches in standard and extended mode found no Mendelian randomisation study of dispositional optimism specifically. Davey Smith, who developed the method, is a co-author, which is why the null carries weight. Wootton is first and corresponding author; author order confirmed at an open bibliographic API.
[STRUCTURED ABSTRACT AND RESULTS PARAGRAPH READ IN FULL AT SOURCE, the BMJ article page; THE FULL BODY WAS NOT READ] Wootton, R. E., Lawn, R. B., Millard, L. A. C., Davies, N. M., Taylor, A. E., Munafo, M. R., Timpson, N. J., Davis, O. S. P., Davey Smith, G., & Haworth, C. M. A. (2018). 'Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study.' BMJ 362, k3788. doi:10.1136/bmj.k3788. THE SINGLE MOST IMPORTANT NEGATIVE RESULT IN THE FILE. Two-sample bidirectional Mendelian randomisation on genome-wide association summary data with participant numbers from 83,198 to 339,224, plus a follow-up in 337,112 UK Biobank participants, across eleven cardiometabolic outcomes including coronary artery disease and myocardial infarction. Result, verbatim: 'Evidence of a causal effect of body mass index on subjective wellbeing was seen; each 1 kg/m2 increase in body mass index caused a -0.045 (95% confidence interval -0.084 to -0.006, P=0.02) standard deviation reduction in subjective wellbeing ... No clear evidence of a causal effect was seen between subjective wellbeing and the other cardiometabolic health measures, in either direction.' The only causal arrow found ran from body mass index to lower wellbeing; the arrow from wellbeing to heart disease was absent in both directions. CONSTRUCT CAVEAT, WHICH MUST PRECEDE ANY USE: the exposure is subjective wellbeing and NOT dispositional optimism, and searches in standard and extended mode found no Mendelian randomisation study of dispositional optimism specifically. Davey Smith, who developed the method, is a co-author, which is why the null carries weight. Wootton is first and corresponding author; author order confirmed at an open bibliographic API.
Written from the sTRUCTURED ABSTRACT AND RESULTS PARAGRAPH READ IN FULL AT SOURCE, the BMJ article page; THE FULL BODY WAS NOT READ.
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Wootton, R. E., Lawn, R. B., Millard, L. A. C., Davies, N. M., Taylor, A. E., Munafo, M. R., Timpson, N. J., Davis, O. S. P., Davey Smith, G., & Haworth, C. M. A. (2018). Evaluation of the causal effects between subjective wellbeing and cardiometabolic health: mendelian randomisation study. BMJ, 362, k3788. doi:10.1136/bmj.k3788