Sex differences in pharmacokinetics predict adverse drug reactions in women
women experience ADRs nearly twice as often as men; of 86 drugs, 76 had higher PK values in women; for 59 drugs with clinically identifiable ADRs, sex-biased PKs predicted the direction of sex-biased ADRs in 88 per cent of cases; 96 per cent of female-biased PK drugs associated with more ADRs in women; only 29 per cent of male-biased PKs predicted male-biased ADRs; not explained by body weight; authors recommend evidence-based dose reductions for women.
women experience ADRs nearly twice as often as men; of 86 drugs, 76 had higher PK values in women; for 59 drugs with clinically identifiable ADRs, sex-biased PKs predicted the direction of sex-biased ADRs in 88 per cent of cases; 96 per cent of female-biased PK drugs associated with more ADRs in women; only 29 per cent of male-biased PKs predicted male-biased ADRs; not explained by body weight; authors recommend evidence-based dose reductions for women.
Written from the abstract read 2026-10-15.
What our sources record
Reproduced as it was written when this source was checked, figures and all.
11, 32. doi:10.1186/s13293-020-00308-5. Abstract read: women experience ADRs nearly twice as often as men; of 86 drugs, 76 had higher PK values in women; for 59 drugs with clinically identifiable ADRs, sex-biased PKs predicted the direction of sex-biased ADRs in 88 per cent of cases; 96 per cent of female-biased PK drugs associated with more ADRs in women; only 29 per cent of male-biased PKs predicted male-biased ADRs; not explained by body weight; authors recommend evidence-based dose reductions for women.